醛氧化酶在药物代谢中的作用

The role of aldehyde oxidase in drug metabolism

目的介绍一种在药物代谢研究中日益重要的非CYP450氧化酶——醛氧化酶(aldehyde oxidase,简称AOX)的研究进展,为深入研究和了解该药物代谢酶提供参考。方法以65篇国内外相关文献为基础,进行分析、归纳和总结,阐明AOX在药物代谢过程中的作用。结果首先对AOX进行了简要介绍,接着描述了AOX的底物类型,不同实验动物的AOX基因(种属差异及对药物代谢和开发的影响),影响AOX活性的因素,AOX代谢决策树(筛选方法),最后对其在药物代谢中的作用进行了总结并展望未来可能的发展方向。结论鉴于AOX在药物代谢中的重要作用,需要研究者们从生物学、酶反应机理、底物专属性等方面更深入地研究AOX。

Objective—To provide a reference for the in-depth understanding and study of aldehyde oxidase（AOX）by summarizing the recent research progress on AOX,which is an increasingly important non-cytochrome P450（CYP450）enzyme in drug metabolism.Methods—On the basis of 65relevant domestic and overseas literatures,the structure,catalytic activity,substrate specificity and genes for AOX are summarized,analyzed and induced to expound the role of AOX in drug metabolism.Results—Firstly,AOX is briefly introduced,and then the substrates for AOX,the species difference of AOX genes,the factors affecting the activity of AOX and the decision tree for the AOX-related drug metabolism were discussed.Finally,the role of AOX in the drug metabolism was summarized and the possible research direction in the future was prospected.Conclusion—In view of the important role of AOX in drug metabolism,the emerging relevance of AOX in drug discovery calls for the comprehensive studies in AOX-related areas,that is,the AOX should be researched from the aspect of biology,enzyme reaction mechanism,substrate specificity,etc.