高危新生儿扭动运动阶段与婴儿痉挛的相关性研究

Study on relationship between high risk newborn writhing movements period and infant spasms

目的探讨高危新生儿扭动运动阶段与婴儿痉挛的相关性,为临床诊治提供有效参考。方法对178例在康复科随访的高危新生儿,在扭动运动阶段进行全身运动质量评估,在12月龄(纠正年龄)后对于发生婴儿痉挛的患儿进行统计分析。结果扭动运动阶段痉挛-同步性运动对于婴儿痉挛有预测性。运动形式具有痉挛同步运动特征的患儿的婴儿痉挛的发病率与单调性全身运动的婴儿相比差异有统计学意义(P<0.01)。痉挛-同步性运动对于婴儿痉挛的预测敏感度90.9%,特异度96.8%,阳性预测值80%,阴性预测值98.7%。结论扭动运动阶段痉挛-同步性运动对于婴儿痉挛有一定的预测价值,该种运动形式的患儿,应定期进行动态脑电图检查。

Objective To investigate the correlation between high risk newborn writhing movements period and infant spasms. Methods A total of 178 high risk infants follow-up in rehabilitation department were accepted the qualitative as- sessment of general movements respectively in the writhing movements period. Statistical analysis of babies with infant spasms was made after 12-month-age（corrected age of premature infants）. Results Cramped-synchronised movements had predictive value for infantile spasms. There was a significant difference in the incidence of infantile spasms between the cramped-synchronised movements and the poor repertoire movements （P〈0.01）. The predictive validity of infant spasms were as follows： sensitivity 90.9 %, specificity 96.8 %, positive predictive value 80%, and negative predictive value 98.7 %. Conclusion Only the cramped-synchronised movements of writhing movements period have predictive value. Infants with cramped-synchronised movements should be regularly carried out 24 hours of dynamic electroencephalogram.