北京地区新生儿先天性甲状腺功能低下症发病趋势研究

Study on neonatal congenital hypothyroidism prevalence trend in Beijing

目的分析北京市先天性甲状腺功能低下症(congenital hypothyroidism,CH)发病率变化和发病趋势,为合理制定CH的防治、保健的策略及措施提供科学依据。方法利用北京市开展新生儿疾病筛查的1994-2011年资料,进行描述性分析及统计推断。结果 18年来,北京市CH的发病率呈逐年上升趋势,平均发病率为31.80/105。2003年CH的实验室检测方法由放免法改为时间分辨荧光免疫分析法,此可能为北京市CH发病率上升的主要原因。结论 1994-2011年北京市CH发病率呈明显上升趋势。

Objective To analyze the change and trend of prevalence of congenital hypothyroidism（CH） ,and to provide scientific support for the establishment of reasonable strategy and measure for the prevention of CH. Method The infor mation from neonatal screening program during 1994-2011 in Beijing were made by descriptive analysis and statistical infer ence. Results The prevalence rate of CH showed upward trend in Beijing during 18 years,the average prevalence rate was 31.80/10^5. In 2003 the laboratory method of CH had been changed from RIA to time-resolved fluorescence immunoassay. which maybe led to the upward trend of the prevalence rate of CH in Beijing. Conclusion The prevalence rate of CH shows upward trend in Beijing during 1994-2011.