阿司匹林与卡托普利合用对麻醉犬血液动力学的影响

Effects of aspirin in combination with captopril on hemodynamics in anesthetized open chest dogs

目的观察阿司匹林(Asp),卡托普利(Cap)单用和合用对麻醉开胸犬血液动力学的作用。方法张力指数(TTI)、左室做功指数(LVWI)、平均动脉压(MAP)、总外周血管阻力(TPVR)、股动脉血流量(FBF)、左室内压(LVSP)、+dp/dtmax、左室舒张末期压(LVEDP)、心率(HR)均同步记录于多导生理记录仪及电磁流量计上。结果Asp5、10mg·kg-1iv对血液动力学各项指标均无明显影响,Cap0.5mg·kg-1iv对LVSP、+dp/dtmax、LVEDP、HR无明显影响 ,CI稍增加 ,但可使TTI、LVWI、TPVR显著下降 ,Asp与Cap 合用与Cap 单用结果相似。

Aim To observe the effects of aspirin in combination with captopril (Cap) on hemodynamics in anesthetized open chest dogs. Methods Tension time index(TTI),left ventricular work index(LVWI),mean arterial pressure (MAP),and total peripheral vascular resistance(TPVR),femoral artery blood flow(FBF),ventricular systolic pressure(LVSP),maximum of its first derivative(+dp/dtmax),left ventricular end diastolic pressure(LVEDP) and heart rate were recorded on polygraph and electromagnetic flower separately when aspirin was administered alone or in combination with captopril.Results The result showed that Asp 5,10 mg·kg-1 had no marked effect on indices of hemodynamics.Cap 0.5 mg·kg-1 iv had no significant effect on LVSP,+dp/dtmax, LVEDP,HR and did not obviously increase cardiac index ( CI) ,but distinctively decreased TTI ,LVWI, MAP, TPVR, and significantly increased FBF. The effect of Asp in combination with Cap was similar to that of Cap alone. Conclusion The improvement of cardiovascular function caused by Cap is not changed in the presence of Asp.