人类8-羟基鸟嘌呤DNA糖苷酶1及着色性干皮病基因D基因多态性与胃癌遗传易感性的关系研究

Relationship between hOGG1 and XPD gene polymorphism and genetic susceptibility of gastric cancer

目的 探讨人类8-羟基鸟嘌呤DNA糖苷酶1（hOGG 1）基因和人类着色性干皮病基因D（XPD）基因多态性与胃癌遗传易感性的关系.方法 收集胜利石油管理局胜利医院98例胃癌患者和80例非肿瘤对照组志愿者,内镜窄带成像（NBI）模式下取出病理组织,应用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测法检测胃癌人群的外周血中DNA损伤修复酶基因多态性,分析其与肿瘤遗传易感性的关系.结果 Lys751 Gln基因型使胃癌的发病风险增加1.5倍（OR值=1.486,0.730 ～3.025）.两基因的交互作用使胃癌的发病风险降低（S＜1,API =0.24）.结论 Lys751 Gln基因型与个体患胃癌疾病的易感性可能有相关性.

Objective To investigate the relationship between hOGG1 and XPD gene polymorphism and genetic susceptibility of gastric cancer.Methods This study was carried out in Dongying Shengli Petroleum Administration Bureau Hospital.Under the narrow band imaging（NBI） mode,the blood samples of a total of 98 gastric cancers and 80 controls without cancers were collected.Genetic polymorphisms of DNA repair genes were identified by polymerase chain reaction restriction fragment length polymorphism（PCR-RFLP）,then its relationship with cancers was analyzed.Results Carrying 326Cys allele with the wine increased the risk of gastric cancer; Lys 751Gln genotype increased the susceptibility of the gastric cancers （OR =1.486,0.73 ～ 3.025）.Conclusion Lys751 Gln genotype increases the risk of gastric cancer.