胎儿宫内发育迟缓与胎儿脐血瘦素、胰岛素样生长因子-1和脂联素的相关性研究

The correlation of leptin, IGF-1 and adiponectin in fetal cord blood with intrauterine growth retardation

目的 分析胎儿宫内发育迟缓与胎儿脐血瘦素、胰岛素样生长因子-1和脂联素的相关性.方法 61例宫内发育迟缓的胎儿作为观察组,80例发育正常胎儿作为对照组,测定两组胎儿脐血的瘦素、胰岛素样生长因子-1（IGF-1）和脂联素.结果 观察组发育迟缓胎儿脐血瘦素、胰岛素样生长因子-1、脂联素水平均明显低于对照组（t=11.239、11.680、13.640,均P＜0.01）.相关分析显示出生体质量与脐血中瘦素、IGF-1和脂联素水平呈正相关（r=0.274、0.532、0.539,均P＜0.05）.结论 胎儿脐血瘦素、胰岛素样生长因子-1和脂联素与宫内发育迟缓有密切关系.

Objective To study the correlation of leptin,insulin-like growth factor-1 （IGF-1） and adiponectin in fetal cord blood with intrauterine growth retardation （IUGR）.Methods Sixty-one fetus with IUGR were enrolled into the observation group and eighty healty fetus were enrolled into the control group.Leptin,IGF-1 and adiponectin were detected.Results The levels of leptin,IGF-1 and adiponectin in the observation group were lower than those in the control group,there were significant differences between the two groups （t =11.239,11.680,13.640,all P 〈 0.01）.The body mass in the observation group was （2 157 ± 243） g,which had significantly positive correlation with leptin （r =0.274,P 〈 0.05）,IGF-1 （r =0.532,P 〈 0.05） and adiponectin （r =0.539,P 〈 0.05）.Conclusion There was a close relationship in leptin,IGF-1 and adiponectin with IUGR.