期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

死亡相关蛋白激酶1与细胞死亡

Death-associated protein kinase 1 and cell death
原文传递
导出
摘要 背景 细胞死亡是多种疾病的伴随过程,死亡相关蛋白激酶1（death-associated protein kinase 1,DAPK1）是一类与细胞死亡有关的酶,最初人们主要研究它在肿瘤抑制方面的作用,随后人们发现它在细胞死亡方面也有重要作用. 目的 DAPK1与细胞死亡密切相关,是近年来的研究热点.了解其研究现状以及未来发展趋势是非常有意义的. 内容 从DAPK1的结构、活性调节等方面人手,着重分析DAPK1与多种作用物的相互作用过程及其与疾病的关系. 趋向 随着人们对DAPK1研究的日益深入,DAPK1将成为疾病治疗的一个新靶点. Background Cell death is accompanied by a variety of diseases.It involves a enzyme called death-associated protein kinase 1 （DAPK1）,which was previously thought to be a tumor suppressor.It was currently demonstrated that DAPK1 also played a pivotal role in cell death.Objective DAPK1 is now a research hotspot for its close links to cell death.It is of great importance to review the current status and future trends of this issue.Content This review describes the structure and activity regulation of DAPK1,focusing on its relationship with a variety of elements and their interaction during the progress of death signaling-related diseases.Trend With the deepening research on this issue,DAPK1 will become a new target for the treatment of diseases.
作者 鲜汶静 姚尚龙 尚游
机构地区 华中科技大学同济医学院附属协和医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2014年第7期651-655,共5页 International Journal of Anesthesiology and Resuscitation
基金 国家自然科学基金项目（81271270） 武汉市科技公关计划项目（2013060501010155）
关键词 细胞死亡相关蛋白激酶1 细胞死亡 神经疾病 Death-associated protein kinase 1 Cell death Nervous disease
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献22

  • 1Jin Y,Blue EK,Dixon S,et al.Identification of a new form of death-associated protein kinase that promotes cell survival[J].J Biol Chem,2001,276(43):39667-39678.
  • 2Jin Y,Blue EK,Gallagher PJ.Control of death-associated protein kinase (DAPK) activity by phosphorylatiou and proteasomal degradation[J].J Biol Chem,2006,281(51):39033-39040.
  • 3Jin Y,Blue EK,Dixon S,et al.A death-associated protein kinase (DAPK)-interacting protein,DIP-1,is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK[J].J Biol Chem,2002,277(49):46980-46986.
  • 4Raveh T,Berissi H,Eisenstein M,et al.A functional genetic screen identifies regions at the C-terminal tail and death-domain of deathassociated protein kinase that are critical for its proapoptotic activity[J].Proc Natl Acad Sci U S A,2000,97(4):1572-1577.
  • 5Shohat G,Spivak-Kroizman T,Cohen O,et al.The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism[J].J Biol Chem,2001,276(50):47460-47467.
  • 6Jang CW,Chen CH,Chen CC,et al.TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase[J].Nat Cell Biol,2002,4(1):51-58.
  • 7Martoriati A,Doumont G,Alcalay M,et al.Dapk1,encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint,is a transcription target of p53[J].Oncogene,2005,24 (8):1461-1466.
  • 8Zhang L,Nephew KP,Gallagher PJ.Regulation of death-associated protein kinase.Stabilization by HSP90 heterocomplexes[J].J Biol Chem,2007,282(16):11795-11804.
  • 9Lin Y,Stevens C,Hupp T.Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis[J].J Biol Chem,2007,282 (23):16792-16802.
  • 10Bialik S1,Berissi H,Kimchi A.A high throughput proteomics screen identifies novel substrates of death-associated protein kinase[J].Mol Cell Proteomics,2008,7(6):1089-1098.

二级参考文献28

  • 1吴伟,史继新,成惠林,孙桂勤,印红霞.脑室内低温对脑局部缺血后神经元凋亡的影响[J].医学研究生学报,2005,18(1):20-22. 被引量：1
  • 2戢翰升,汪林涛,徐峰,唐振刚.重型颅脑损伤亚低温治疗的温度、时机和时程对疗效的影响[J].中国临床神经外科杂志,2005,10(1):45-46. 被引量：30
  • 3王光伟,刘运生,赵林,屈洪涛,梁有明,李创华.亚低温对大鼠脑损伤后脑组织炎性反应的影响[J].中华创伤杂志,2005,21(6):443-446. 被引量：15
  • 4Pulsinelli WA, Jacewicz M, Levy DE, et al. Isehemic brain injury and the therapeutic window. Ann N Y Acad Sci, 1997, 835(19): 187-193.
  • 5Castellanos M, Sobrino T, Castill J. et ah Evolving paradigms for neuroprotection: molecular identification of ischemic penumbra. Cerebrovas Dis, 2006, 21(suppl2): 71-79.
  • 6Zhao H, Yenari MA, Cheng D, et al. Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia. J Cereb Blood Flow Metab, 2005, 25(9): 1119-1129.
  • 7Zhang Z, Sobel RA, Cheng D, et al. Mild hypothermia increases Bc1-2 protein expression following global cerebral ischemia. Brain Res Mol Brain Res, 2001, 95(1-2): 75-85.
  • 8Zhao WH, Ji XM, Ling F, et al. Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats. Neurol Res, 2009, 31 ( 1 ) : 43-51.
  • 9Lee SM, Zhao H, Maier CM, et al. The protective effect of early hypothermia on PTEN phoshorylation correlates with free radical inhibition in rat stroke. J Cereb Blood Flow Metab, 2009, 29(9): 1589-1600.
  • 10Takata K, Takeda Y, Sato T, et al. Effects of hypothermia for a short period on histologie outcome and extracellular glutamate concentration during and after cardiac arrest in rats. Crit Care Med, 2005, 33(6): 1340-1345.
国际麻醉学与复苏杂志
2014年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部