摘要
线粒体是机体代谢和能量合成的重要场所,其功能损伤与糖尿病的发病有密切联系.线粒体跨膜电位超极化、解耦联蛋白2表达异常、线粒体自噬障碍引起线粒体功能或结构受损,导致活性氧簇的产生过多,加重胰岛素抵抗.线粒体自身甲状腺激素受体活性对胰腺转录因子的表达也有调节作用,间接影响胰岛素的分泌水平.同时,线粒体基因不同位点的变异与糖尿病发病易感性相关.了解线粒体损伤与糖尿病发病的相关机制将为糖尿病的治疗提供新的思路.
Mitochondria is an important place of metabolism and energy synthesis.Dysfunction of mitochondrial is closely related to diabetes.Excessive expression of reactive oxygen species（ROS）,caused by the hyperpolarization of mitochondrial transmembrane potential,the abnormal expression of uncoupling protein 2 and impairment of autophagy which causes mitochondrial dysfunction and structural damage,accelerates the progress of insulin resistance.Mitochondria expresses have their own thyroid hormone receptors,which can modulate the expression of pancreatic transcription factors and affect the secretion of insulin indirectly.Meanwhile,the mutation of mitochondrial gene is associated with susceptibility of diabetes.Understanding the relationship between mitochondrial damage and diabetes will provide new ideas for the treatment of diabetes.
出处
《国际内分泌代谢杂志》
北大核心
2014年第4期271-273,280,共4页
International Journal of Endocrinology and Metabolism
基金
国家卫生和计划生育委员会（W201309）
关键词
线粒体
糖尿病
活性氧簇
解耦联蛋白2
自噬
Mitochondria
Diabetes mellitus
Reactive oxygen species
Uncoupling protein 2
Autophagy
