补肾健脾法对高龄冻融胚胎反复移植失败患者胚胎质量的影响

Influence of Reinforcing Kidney and Invigorating Spleen Method on Embryo Quality of Elderly Repeated Thawing Embryo Transfer Women

目的:观察中医补肾健脾法对高龄冻融胚胎反复移植失败患者胚胎质量的改善情况。方法:将66例35岁以上冻融胚胎反复移植失败患者随机分为治疗组(33例)和对照组(33例),对照组行IVF促排卵、取卵和胚胎冷冻治疗,治疗组采用补肾健脾中药服用3个月后接受与对照组同样的治疗。观察并计算两组及按年龄分层后各组获卵数、优质卵率、胚胎数、优质胚胎数、优胚率。结果:随着年龄的增长,治疗组、对照组妇女的获卵数、胚胎数、优胚数均减少,但治疗组下降趋势较缓慢。66个取卵周期,治疗组的优质卵率、优胚率均高于对照组(P<0.05)。结论:补肾健脾法可以减缓高龄患者卵子质量下降,能明显提高其优质卵率及优胚率。

Objective：To observe the improvement of reinforcing kidney and invigorating spleen principle on embryo quality of elderly repeated thawing embryo transfer failure women.Methods：A total of 66 patient cases were randomly divided into treatment group（33 cases） and control group（33 cases）,all undergoing IVF ovulation,egg retrieval and embryo freezing in the Shanghai Ninth People＇s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,while the treatment group patients took herbs according to reinforcing kidney and invigorating spleen mechanism three months before.The number of oocytes,embryos,high-qualitied embryos,the ratio of mature oocytes,and the high-qualitied embryos were observed and calculated in both groups.Then calculated once more after stratification by age groups.Results：With age,there was a trend that the number of oocytes,embryos,and high quality embryos reduced in both groups,the trend became more moderate in treatment group than control group.ratio of mature oocytes and highqualitied embryos of treatment group were higher than control group in 66 COH cycles（P〈0.05）.Conclusion：reinforcing kidney and invigorating spleen principle can slow down the decline in the quality of elderly patients with egg,can significantly improve the quality of eggs and the excellent rate of embryos.