复方丁香开胃贴治疗重型颅脑损伤后胃肠功能障碍的疗效观察

Effect of Compound Dingxiang Kaiwei Paste in Treating Gastrointestinal Dysfunction after Severe Craniocerebral Injury

目的:观察复方丁香开胃贴治疗重型颅脑损伤患者胃肠功能障碍的疗效,为临床治疗提供经验和帮助。方法:将医院重症医学科收治符合条件的92例重型颅脑损伤的术后病人随机分为治疗组(n=48)和对照组(n=44),治疗组予鼻饲吗丁啉混悬液,复方丁香开胃贴外贴神阙穴,对照组仅鼻饲吗丁啉悬液,余治疗均相同,观察肠鸣音恢复时间、术后首次肛门排气、排便时间,血清胆囊收缩素(cholecystokinin,CCK),瘦素(leptin)水平变化情况以及上消化道出血发生率,了解胃肠功能恢复情况。结果:治疗组治疗后肠鸣音、肛门排气排便时间均较对照组缩短,血清CCK水平均下降,应激性上消化道出血率较对照组低(P均<0.05),但血leptin无统计学差异。结论:复方丁香开胃贴贴敷神阙穴可明显改善颅脑损伤术后病人的胃肠功能障碍,并有效减少消化道并发症,血清CCK可能参与这过程。

Objective：To observe the effect of compound Dingxiang Kaiwei Paste in treating gastrointestinal dysfunction after severe craniocerebral injury and provide experience for the clinical treatment.Methods：92 patients with severe craniocerebral injury admitted to hospital were randomly divided into treatment group（n = 48） and control group（n =44）.The treatment group was given nasal feeding motilium suspension and the compound Dingxiang Kaiwei Paste was applicated to Shenque point.The control group only used nasal feeding motilium suspension.The rest were the same treatment.And then the differences in bowel sound recovery time and the time for passage of gas by anus and the bowel movement time and the incidence of upper gastrointestinal bleeding with in the two groups were observed.Results：The time of bowel sound recovery,gas passage time by anus,the bowel movement time,the level of serum CCK and the incidence of upper gastrointestinal bleeding rate in the treatment group were significantly reduced compared with those of the control group（P〈 0.05）,but the level of serum leptin was similar.Conclusion：Applicating the compound Dingxiang Kaiwei Paste on Shenque point could significantly improve gastrointestinal dysfunction and effectively reduce gastrointestinal complications and the CCK may be involved in this process.