米非司酮胶囊联合地诺前列酮栓用于未足月引产的临床研究

Clinical research of mifepristone capsules combined with dinoprostone in preterm labor induction of late pregnancy

目的：观察米非司酮胶囊（米福）联合地诺前列酮栓（欣普贝生）用于终止晚孕未足月（196～258d）引产的临床效果。方法：将有引产指征的晚孕未足月孕妇根据引产方式的不同分为3组,分别采用欣普贝生（A组）,米福联合缩宫素（B组）及米福联合欣普贝生（C组）方法引产,比较3组的引产效果。结果：3组对象年龄、孕次、妊娠时间、胎儿体重、用药前宫颈评分无统计学差异（P＞0.05）。C组与B组、A组分别比较,用药后6h和12h宫颈评分高,宫缩发动时间短及产程短,产后出血量少,引产成功率高,差异均有统计学意义（P〈0.05）。C组清宫率低于A组（P〈0.05）,与B组无统计学差异（P＞0.05）。结论：米非司酮胶囊联合地诺前列酮栓用于晚孕未足月引产临床效果优于本研究其他两种引产方法。

Objective： To evaluate the clinical effect of mifepristone capsules combined with dinoprostone in preterm labor induction of late pregnancy. Methods： According to different ways of abortion, late pregnancy women who had preterm induced labor indications were divided into 3 groups. Women in Group A were placed dinoprostone in the posterior fornix, and those in group B took mifepristone capsules combined with intravenous drip of oxytocin, and those in group C received mifepristone capsules combined with dinoprostone. The effects of induced labor of the three groups were evaluated. Results： There were no significant differences in age, gravidity, duration of pregnancy, fetal weight, cervical Bishop score among three groups before the treatment （P all〉0.05）. Compared with group B and group A, higher cervical Bishop scores 6h and 12h after the treatment, shorter contraction start time, shorter labor stage, less postpartum bleeding and higher successful rate of induced labor were found in group C （P all 〈0.05）. The curettage rate was lower in group C than group A （P〈0.05）, while similar with that of group B （P〉0.05）. Conclusion： Mife- pristone capsules combined with dinoprostone is superior to the other methods in preterm labor induction of late preg- nancy.