持续小剂量静脉输注头孢他啶治疗下呼吸道感染的临床研究

Clinical study of low dose continuous infusion of ceftazidime (CAZ)forthe treatment of low respiratory tract infections

目的采用输液泵持续小剂量静脉输注头孢他啶 ,探讨与间断给药相比持续给药的合理性、有效性、安全性和经济性。方法53例患者随机分为实验组 (30例 )和对照组 (23例 )。对照组静滴头孢他啶1g,bid ;实验组应用输液泵持续小剂量静脉输注头孢他啶 (开始时加一负荷量1g)。结果实验组与对照组相比 ,临床治愈率分别为73.3 %和73.9 %;有效率分别为90.0 %和91.3 %;细菌清除率分别为86.7 %和82.7 %,均无明显差异 (P>0.05)。结论对于下呼吸道G -杆菌感染的患者 ,持续小剂量静脉输注头孢他啶是合理、有效、经济的。

Aim This experiment was designed to probe whether low dose (1 g·d-1) continuous infusion of CAZ is safe, efficacious and low costing in the treatment of infections in low respiratory tract . Methods The patients were divided into control group and treatment group at random. The routine administration (1 g,bid) of CAI was adopted in the treatment group, while the low dose continuous infusion method (1 g·d-1, and a loading dose 1 g) was used in the control group. Results In the control group and the treatment group, the clinical curative rates were 73.3% and 73.9%, the efficacy rates were 90.0% and 91.3%,the bacterial clearance rates were 86.7% and 82.7% and the adverse effect rates were 6.7% and 8.7% respectively. There was no significant difference between the two groups (P>0.05). Conclusions Low dose continuous infusion of CAZ to treat low respiratory infections is efficacious ,safe and economical.