抗HCV治疗对HCV/HIV混合感染者白细胞及CD4细胞影响的探讨

Influence of anti HCV treatment on white blood cells and the CD4 cells of HCV/HIV mixed infection

目的了解抗HCV治疗对HCV/HIV混合感染者白细胞及CD4细胞的影响。方法回顾分析本科收治的12例HCV/HIV混合感染者在抗HCV治疗过程中白细胞及CD4细胞变化情况。结果 12例接受PEG-IFNα-2a联合利巴韦林抗病毒治疗者,均出现不同程度的白细胞及CD4细胞计数的减少。其中同时使用含有齐多夫定的HAART方案者白细胞及CD4细胞计数减少最为明显。结论对于HCV/HIV混合感染者,在抗HCV治疗过程中应密切注意白细胞及CD4细胞的变化,抗HCV治疗前应尽可能更换含有齐多夫定片的HAART治疗方案。

Objective To explore influence of anti HCV treatment on white blood cells and the CD4 cells of HCV/HIV mixed infection. Methods Retrospective analysis of 12 patients admitted in our department HCV/HIV mixed infection in anti HCV treatment process, the change of the white blood cells and the CD4 cells. Results All 12 patients with PEG-IFNα-2a plus ribavirin antiviral treatment, white blood cells and CD4 cells in different levels of decrease. Which at the same time with zidovudine HAART scheme of white blood cells and CD4 cell count to reduce the most obvious. Conclusion For people infected with HCV/HIV mixed in the process of anti HCV treatment should pay close attention to the change of the white blood cells and the CD4 cells, anti HCV treatment should be replaced as soon as possible before contains zidovudine tablets of HAART treatment.