泮托拉唑、曲美布汀联合氟哌噻吨美利曲辛片治疗胃食管反流病的疗效分析

Analysis of Pantoprazole,Trimebutine Combined with Flupentixol and Melitracen Tablets in the Treatment of Gastroesophageal Reflux Disease

目的:探讨泮托拉唑、曲美布汀联合氟哌噻吨美利曲辛片治疗胃食管反流病的临床疗效。方法:选取2012年1月-2013年10月本院收治的胃食管反流病患者120例,按患者自愿原则分为试验组63例和对照组57例,试验组采用泮托拉唑、曲美布汀联合氟哌噻吨美利曲辛片治疗;对照组予泮托拉唑和曲美布汀治疗,疗程均为4周。比较两组患者的临床治疗效果、停药3个月后复发率及不良反应发生率。结果:试验组总有效率高于对照组,差异有统计学意义(P<0.05);停药3个月后试验组复发率低于对照组,差异有统计学意义(P<0.05);治疗后试验组SAS、SDS值均明显降低,与对照组比较差异均有统计学意义(P<0.01);治疗过程中两组均未发生明显不良反应。结论:泮托拉唑、曲美布汀联合氟哌噻吨美利曲辛片治疗胃食管反流病能有效改善临床症状,并能有效预防其复发,疗效显著,值得临床中推广应用。

Objective：To observe clinical curative effect of Pantoprazole, Trimebutine combined with Flupentixol and Melitracen tablets in the treatment of gastroesophageal reflux disease.Method：120 cases of gastroesophageal reflux disease in our hospital from January 2012 to October 2013 were selected, and they were divided into the experimental group for 63 cases and the control group for 57 cases according to the patients with voluntary basis. The experimental group was treated with Pantoprazole, Trimebutine combined with Flupentixol and Melitracen tablets; the control group was given Pantoprazole, Trimebutine, a course of 4 weeks. The clinical therapeutic effect and drug withdrawal after 3 months,the recurrence rate and adverse reactions were compared between the two groups.Result：The total effective rate of the experimental group was higher than the control group, the difference was statistically significant （P〈0.05）; Withdrawal after 3 months, the recurrence rate of the experimental group was lower than the control group, the difference was statistically significant（P〈0.05）; after treatment, SAS, SDS value of the experimental group were significantly lower, compared with the control group were statistically significant difference （P〈0.01）; patients of the two groups had no obvious adverse reaction in treatment.Conclusion： Pantoprazole, Trimebutine combined with Flupentixol and Melitracen tablets in the treatment of gastroesophageal reflux disease can effectively improve the clinical symptoms, and can effectively prevent its recurrence, curative effect is distinct, is worth popularizing in clinical application.