图像引导放疗治疗颈段、胸上段食管癌疗效观察

The Effect of Image-guided Radiation Therapy for Cervical and Upper-thoracic Esophageal Cancer

目的:观察颈段、胸上段食管癌行图像引导放射治疗(image-guided radiation therapy,IGRT)的疗效和不良反应。方法:回顾性分析32例颈段、胸上段食管癌患者接受图像引导放射治疗的疗效,局部区域控制率和总生存率用Kaplan-Meier法计算,并评价其毒副反应。结果:近期总有效率(CR+PR)为93.7%,1、2年局部控制率分别为84.3%、71.8%。1、2年生存率分别为75.0%、62.5%。急性放射反应主要是1、2度急性放射性食管炎,放射性气管炎,白细胞减少。结论:颈段胸上段食管癌行IGRT治疗疗效肯定,副反应小,临床值得推广。

Objective： To observe the effects and side effects of （image-guided radiation therapy, IGRT） in the treatment of cervical and upper-thoracic esophageal carcinoma.Method： 32 cases with cervical and upper-thoracic esophageal carcinoma treated with IGRT were collected, their clinical data were analyzed retrospectively, acute toxi-cities and local control rates and overall survival rates were evaluated by Kaplan-Meier method.Result： The overall response rate （CR＋PR） was 93.7%, the 1,2 year local control rate was 75%, 62.5% respectively, the 1,2 year overall survival rate was 75%, 62.5% respectively. Grade Ⅰ-Ⅱ acute esophagitis and bronchitis and decrease of white blood cells were the most common radiation side effects.Conclusion： IGRT can be considered as an effective and feasible approach to cervical and upper-thoracic esophageal carcinoma treatment, the side effects are slight. It’s worth promoting in clinical practice.