非痴呆型血管认知功能障碍危险因素分析

Analysis of risk factors for vascular cognitive impairment without dementia

目的探讨慢性脑供血不足(CCCI)致非痴呆型血管认知功能障碍的危险因素。方法将120例CCCI患者根据临床痴呆评定量表(CDR)分为非痴呆性血管性认知功能障碍组(VCIND组,52例)及非VCIND组(68例),建立logistic回归模型,分析CCCI患者高血压、糖尿病、高脂血症、脑梗死等各种危险因素与VCIND的关系。结果单因素分析结果显示糖尿病、脑梗死的多次发作及多部位发生及低教育程度与CCCI致VCIND有关;多因素分析证实糖尿病、脑梗死的多次发作及多部位发生及低教育程度与CCCI致VCIND有关,OR值分别为13.255、12.862、9.051、1.486(P<0.01)。结论糖尿病、脑梗死的多次发作及多部位发生、低教育程度与CCCI致VCIND有关,可能是CCCI致VCIND的独立危险因素。

Objective To evaluate the risk factors of vascular cognitive impairment without dementia（ VCIND） induced by CCCI. Methods 120 patients with CCCI were divided into VCIND group（ n = 52） and control group（ n = 68） by the clinical dementia ratio scale（ CDR）. The relationship between VCIND and each risk factor（ hypertension,diabetes mellitus,hyperlipidemia cerebral infarction） was analyzed by logistic-regression models. Results Univariate analysis showed that diabetes mellitus,multiple sites and multiple episodes of cerebral infarction,low educational attainment were significantly associated with the vascular cognitive impairment induced by CCCI, logistic regression analysis indicated that diabetes mellitus（ OR = 13. 255）,multiple sites（ OR =12.862） and multiple episodes（ OR = 9. 051） of cerebral infarction,low educational attainment（ OR = 1. 486） were the independent risk factors（ P〈 0. 05）. Conclusions Diabetes mellitus,multiple sites and multiple episodes of cerebral infarction,low educational attainment are associated with VCIND,and they may be the independent risk factors of VCIND induced byCCCI.