新生儿缺氧缺血性脑病伴胃肠功能障碍的临床分析

Clinical Analysis of Neonatal Hypoxic-ischemic Encephalopathy with Gastrointestinal Dysfunction

目的:分析研究新生儿缺氧缺血性脑病伴胃肠功能障碍的临床特点,并观察多巴胺对新生儿缺氧缺血性脑病伴胃肠功能障碍的治疗效果。方法:选择2011年7月-2014年1月笔者所在医院收治的新生儿缺氧缺血性脑病伴胃肠功能障碍患儿共48例为临床研究对象,随机分为两组。试验组患儿24例给予小剂量多巴胺联合常规治疗,对照组仅给予常规治疗,观察比较两组患儿治疗效果、治疗疗程等。结果:试验组患儿给予小剂量多巴胺治疗,其总有效率达95.83%,明显高于对照组患儿,差异有统计学意义(P<0.05)。试验组患儿治疗后腹部体征消失时间为(1.94±0.64)d、临床症状消失时间为(3.18±1.36)d、疗程为(3.98±0.78)d,明显短于对照组,差异有统计学意义(P<0.05)。结论:新生儿缺氧缺血性脑病伴胃肠功能障碍给予小剂量多巴胺治疗的效果较好,可以快速缓解临床症状及体征,缩短治疗疗程,降低患者的胃肠功能损伤情况。

Objective：To analyze the clinical features of neonatal hypoxic-ischemic encephalopathy with gastrointestinal dysfunction,and observe the effect of neonatal hypoxic-ischemic encephalopathy with gastrointestinal dysfunction with Dopamine.Method：From July 2011 to January 2014 in our hospital 48 cases neonatal hypoxic-ischemic encephalopathy with gastrointestinal dysfunction were randomly divided into two groups.Children in the experimental group（n=24） were given low dose Dopamine and conventional therapy,the control group（n=24） was treated with conventional therapy,the effect and treatment of two groups were observed.Result：The experimental group was given small dose Dopamine treatment,the total effective rate was 95.83%,was significantly higher than that in the control group,the difference has statistical significance（P〈0.05）.In the experimental group after the treatment of abdominal signs disappeared time was （1.94±0.64）d,the disappearing time of clinical symptoms was （3.18±1.36）d,the course of treatment was （3.98±0.78）d,were significantly shorter than the control group,the differences were statistical significance（P〈0.05）.Conclusion：Neonatal hypoxic-ischemic encephalopathy with gastrointestinal Dysfunction with small dose Dopamine has good effect,can rapidly relieve clinical symptoms and signs,shorten the course of treatment,reduce the patient＇s gastrointestinal function damage.