美托洛尔缓释片对慢性心力衰竭患者心功能及心率变异性的影响

Effect of Metoprolol Sustained-release Tablets on Cardiac Function and Heart Rate Variability in Patients with Chronic Heart Failure

目的：探讨美托洛尔缓释片对慢性心力衰竭（ CHF ）患者心功能及心率变异性的影响。方法：将62例CHF患者随机分为观察组32例和对照组30例。观察组在常规心衰治疗基础上加用美托洛尔缓释片，对照组给予常规心衰治疗。12个月后，比较两组患者治疗前后心率（ HR）、总有效率、左室射血分数（ LVEF）、左室收缩末期容积（ LVESV）、左室舒张末期容积（LVEDV）、 N末端B型脑钠肽（NT-proBNP）以及心率变异性（HRV）的变化。结果：观察组患者总有效率、 LVEF及HRV显著高于对照组，而HR、 LVESV、 LVEDV、 NT-proBNP 显著低于对照组。差异均有统计学意义。结论：在常规心衰综合治疗基础上，加用美托洛尔缓释片能有效提高CHF患者的临床疗效，明显改善心室重构、心率变异性及心功能，提高患者生活质量，有利于慢性心力衰竭患者的二级预防。

OBJECTIVE： To approach the curative effect of metoprolol sustained -release tablets on cardiac function and heart rate variability in patients with chronic heart failure .METHODS： 62 patients with chronic heart failure （ CHF） were randomly divid-ed into the observation group （n=32） and control group （n=30）.The observation group received additional metoprolol sustained -release tablets and the control group were randomly treated routine therapy .After 12 months the changes of total effective rate , blood pressure, heart rate, left ventricular eject fraction （LVEF）, left ventricular end-diastolic volume （LVEDV）, left ventricular end-systolic volume （LVESV）, N-terminal pro-brain natriuretic peptide （NT-proBNP） and heart rate variability （HRV） before and after treatment were compared in this two groups .RESULTS： Total effective rate, heart rate, left ventricular eject fraction （ LVEF） and heart rate variability （ HRV） in depression group were higher than those in control group .But left ventricular end -di-astolic volume （LVEDV）, left ventricular end -systolic volume （LVESV） and N-terminal pro-brain natriuretic peptide （NT-proBNP） were significantly lower .There were significantly statistical difference .CONCLUSIONS： Extra use of metoprolol sustained-release tablets combined with routine therapy can effectively increase the therapeutic effect , significantly improve ventricular remode-ling, cardiac function and heart rate variability , and enhance patients ’ life quality, which is helpful to secondary prevention of pa-tients with CHF .