高压氧联合补阳还五汤治疗急性脑梗死认知功能障碍60例临床观察

Clinical observation of hyperbaric oxygen combined with Buyang Huanwu decoction on the treatment of cognitive impairment in patients with acute cerebral infarction

目的观察高压氧联合补阳还五汤治疗急性脑梗死认知功能障碍的临床疗效及安全性。方法将120例急性脑梗死认知功能障碍患者随机分为2组。对照组60例接受高压氧治疗,治疗组60例在对照组治疗基础上予补阳还五汤治疗。2组10 d为1个疗程,2个疗程后统计疗效,并应用简易智能精神状态量表(MMSE)、日常生活活动量评分(ADL)及美国国立卫生研究院卒中量表(NIHSS)分别观察2组治疗前后认知功能、生活自理情况及神经功能缺损程度,观察2组治疗前后血液流变学指标变化。结果治疗组疗效优于对照组(P<0.05);2组治疗后比较,治疗组MMSE、ADL评分均高于对照组(P<0.05),治疗组NIHSS评分低于对照组(P<0.05);治疗组血浆黏度、纤维蛋白原低于对照组(P<0.05),治疗组凝血酶原时间、凝血酶时间及部分凝血活酶时间长于对照组(P<0.05)。结论高压氧联合补阳还五汤可有效改善急性脑梗死认知功能障碍患者脑部缺血性损害状态,从而有助于其认知功能的恢复,对改善患者日常生活功能具有重要意义,且安全性良好,无明显毒副作用。

Objective To observe the clinical efficacy and safety of hyperbaric oxygen combined with Buyang Huanwu decoction on the treatment of cognitive impairment in patients with acute cerebral infarction. Methods120 acute cerebral infarction patients with cognitive impairment were randomly divided into treatment group and control group. 60 cases in control group were treated by hyperbaric oxygen therapy,60 cases of the treatment group received hyperbaric oxygen combined with Buyang Huanwu decoction treatment,After two courses the clinical efficacy of two groups were compared by MMSE,ADL and NIHSS. Results The total effective rate of treatment group is significantly higher than the control group. After treatment MMSE,ADL score in the treatment group was significantly higher than the control group,the NIHSS score was significantly lower than that of the latter（ P〈 0. 05）; after treatment,the treatment group plasma viscosity,fibrinogen was significantly lower than that of the control group,the prothrombin time,thrombin time and activated partial thromboplastin time was significantly higher than the latter. Conclusion Hyperbaric oxygen combined with Buyang Huanwu decoction can effectively improve the cognitive impairment in acute cerebral infarction patients ischemic brain damage state,so as to contribute to the recovery of cognitive function,and has important significance to improve the ability of daily life of patients,and good security,no obvious side effect,is worthy of clinical application.