屈螺酮炔雌醇片促进人工流产术子宫恢复及减少并发症的作用

Effect of Drospirenone and Ethinylestradiol tablets to promote uterine recovery and reduce complications after artificial abortion

目的探讨屈螺酮炔雌醇片对促进人工流产术子宫恢复和减少并发症的临床作用。方法回顾性分析马鞍山市中心医院收治的116例行人工流产术患者的临床资料,根据治疗方式不同分为治疗组和对照组各58例,对照组患者术后给予抗生素预防感染和收缩子宫类药物促进子宫收缩,治疗组患者在对照组的基础上加用屈螺酮炔雌醇片,比较术后两组患者阴道出血时间、阴道出血量、月经复潮时间和子宫内膜厚度以及并发症发生情况。结果治疗组患者阴道出血时间、阴道流血量、月经复潮时间分别为(6.84±2.13)d、(47.34±8.04)mL、(25.48±5.85)d,均显著少于或短于对照组的(8.23±3.72)d、(63.86±9.35)mL、(32.34±6.33)d,差异有统计学意义(P<0.05);子宫内膜厚度观察组为(8.59±2.17)mm,显著厚于对照组的(5.87±1.43)mm,差异有统计学意义(P<0.05);治疗组患者并发症总发生率为13.79%,对照组患者并发症总发生率为15.52%,两组差异有统计学意义(P<0.05)。结论人工流产术后口服屈螺酮炔雌醇片,显著缩短了阴道流血时间、促进月经周期恢复和子宫恢复,并发症发生率明显降低。

Objective To investigate the effect of Drospirenone and Ethinylestradiol tablets,named as Yasmin,to promote uterine recovery and reduce complications after artificial abortion.Methods A total of 116patients with artificial abortion were divided into treatment group and control group,with 58patients for each group.Patients in control group were given antibiotics to prevent infection and related drugs to promote uterine contraction,and patients in treatment group,were treated with Yasmin,except the treatment of control group.Postoperative vaginal bleeding time,vaginal bleeding volum,menstruation time,endometrial thickness and occurrence of complications were compared between the two groups.Results In treatment group,the vaginal bleeding time,vaginal bleeding volume and menstruation time were（6.84±2.13）d,（47.34±8.04）mL and（25.48±5.85）d,which were less than the（8.23±3.72）d,（63.86±9.35）mL and（32.34±6.33）d of control group（P〈0.05）.The endometrial thickness was（8.59±2.17）mm in treatment group,which was higher than the（5.87±1.43）mm of control group（P〈0.05）.The overall incidence of complications in treatment group was 5.17%,which was lower than the 13.79%of control group（P〈0.05.Conclusion Oral taking of Yasmin could shorten vaginal bleeding time,promote restoration of menstruation and recovery of uterus,and reduce the incidence of complications after artificial abortion.