摘要
雾化吸入剂属于肺部药物传递系统中的一种,它能将药物输送到呼吸道和肺部,并使药物直接作用于传递部位或在传递部位被吸收,从而达到湿润黏膜、消炎祛痰、解痉、平喘等作用,它还具有吸收面积大、起效迅速、靶向定位给药、能避免肝脏首过效应等优点,非常适合治疗上呼吸道感染及呼吸系统疾病。近年来肺部吸入制剂发展迅速,取得了巨大的进步,文章对其国内外的研究进展进行综述,并对存在的问题给予分析及总结,希望能为肺部给药系统的研发提供一些理论基础及新思路。
Atomization inhalation which belongs to the pulmonary drug delivery system（PDDS）, delivers drugs to the respiratory tract and lungs, and makes the drugs directly act on the transmission parts or be absorbed in transmission parts, in order to achieve the moist mucosa, anti-inflammatory and expectorant, anti-spasmodic, relieving asthma and so on. It also has a large absorption area, rapid effect, targeting drug delivery, and avoiding the liverfirst-pass effect etc, which is very suitable for the treatment of upper respiratory tract infection and respiratory system disease. Lungs inhalation-preparation has developed rapidly in recent years and made great progress. This paper reviewed the research in domestic and abroad, and some problems were given the analysis and summary, hope to provide some theoretical basis and new ideas for the development of pulmonary drug delivery system.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2014年第7期2084-2088,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
江西省教育厅科学技术研究项目(No.GJJ13609)
江西中医学院自然科学研究项目(No.2012ZR027)
“江西省高等学校卓越人才培养计划”(制药工程)~~
关键词
雾化吸入剂
肺部药物传递系统
雾化器
中药
Nebulized inhalation
Pulmonary drug delivery system
Nebulizer
Traditional Chinese medicine
