基于倾向评分法的丹红注射液联合使用胰岛素安全性研究

Security study based on the propensity score method of Danhong Injection combined with insulin

目的:评价临床丹红注射液配伍使用胰岛素的安全性。方法:采用医院集中监测法收集丹红注射液与胰岛素合并使用信息,使用倾向评分法进行数据处理分析,比较与Logistic回归得出的OR值。结果:倾向评分法和传统Logistic回归法得出丹红注射液不良反应与是否联合使用胰岛素的OR值分别为0.19[0.03,1.41]和0.22[0.03,1.57]。结论:联合使用胰岛素不会增加丹红注射液的用药风险。

Objective： To evaluate the safety of Danhong Injection combined with insulin in clinical. Methods： The information of Danhong Injection combined with insulin was collected by using the method of hospital centralized monitoring. The results were statistically analyzed by using the propensity score method and the Logistic regression analysis. To compare two dif erent results. Results： The OR values of Danhong Injection ADR and whether combined with insulin or not were 0.19 [0.03, 1.41] and 0.22 [0.03, 1.57]respectively by using the propensity score method and the traditional Logistic regression. Conclusion： Danhong Injection combined with insulin could not increase the risk of medication.