中医动物模型研制方法及展望

Development and prospect of establishment method of traditional Chinese medicine animal models

标准化中医动物模型是推动中医药现代化的重要环节。文章通过回顾中医传统病因动物模型、模拟西医病因病理动物模型、病证结合动物模型的研制方法,认为病证结合动物模型是现代中医药研究模式的发展趋势。病证结合模型是比较理想的动物模型,具有符合中医理论,贴近中医证候特点,稳定性、可靠性及可实用性强等优势。虽然病证结合动物模型仍处于探索阶段,但是随着病证结合动物模型研制技术和思维方式的创新、模型评价系统的规范、模型制备因素的纯化、药物反证方法的完善等,将有望成为揭示中医证候内涵,推动中医现代化发展的重要途径。

The standardization of animal models of traditional Chinese medicine is an important link in promoting modernization of TCM. This paper reviewed the animal models of traditional etiology of TCM, modern medicine etiology and pathology and combination of disease and syndrome, and regarded the animal model of combination of disease and syndrome as a new development trend of the modern research of TCM. The animal model of combination of disease and syndrome is the ideal animal model, and it has many advantages such as conform to the theory of TCM, close to the characteristics of TCM syndrome, stabilization, reliable and practicable. Although animal model of combination of disease and syndrome is still in the exploratory stage, with the innovation of research method in technology and way of thinking, the specii cation of model evaluation system, the purii cation of preparation factors, the improvement of drug counterevidence method, it will be expected to the important force to reveal the essence and promote the modernization of TCM.