肝硬化疾病诊断中的生化检验的价值研究

The clinical value of biochemical test in the diagnosis of cirrhosis

目的探讨肝硬化疾病诊断中生化检验的临床价值，为今后临床诊断与检验工作提供可靠依据。方法选取我院2011年3月—2013年3月收治的肝硬化患者68例作为观察组，同时选取同期健康体检者68例作为对照组，2组分别进行各项生化指标检测。结果观察组患者天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、碱性磷酸酶（ALP）、γ-谷氨酰转肽酶（γ-GT）、总胆红素（TBIL）、直接胆红素（DBIL）、血清透明质酸（HA）、Ⅲ型前胶原（Pc—Ⅲ）、层粘连蛋白（LN）、Ⅳ型胶原（IV—C）检测结果显著高于对照组（P〈0．01），而观察组患者胆碱酯酶（ChE）、总蛋白（TP）、白蛋白（Alb）检测结果均显著低于对照组（P〈0．01）。结论对肝脏多项生化指标进行检测能够为临床诊断肝硬化提供可靠的参考依据，有利于提高临床诊断率，值得引用和关注。

Objective To explore the clinical value of biochemical test in the diagnosis of cirrhosis, and provide reliable evidence for clinical diagnosis and testing. Methods 68 patients with cirrhosis from Mar. 2011 to Mar. 2013 in study group,and 68 healthy people in controlled group. Both groups were taken biochemical test and comparison was made between two groups. Results The results of AST, ALT, ALP, γ-GT, TBIL, DBIL, HA, PC -Ⅲ, LN and Ⅳ-C in study group were significatly higher than controlled group （ P 〈 0.01 ）. The results of CHE, TP and ALB in study group were lower than controlled group （P 〈0. 01 ）. Conclusion Taking biochemical test to liver can provide reliable evidence for the clinical diagnosis of cirrhosis, which is worthy of promoting.