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胰岛细胞移植术后远期疗效维持的研究进展

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摘要 自1974年,明尼苏达大学Sutherland等实施了世界上首例人胰岛细胞移植治疗1型糖尿病以来[1],到今天已经有将近40年的临床历史了.然而胰岛细胞移植术后的临床疗效仍然欠佳.有报道显示[2],尽管临床上已经改良实施了Edmonton方案,在胰岛细胞移植术1 000 d后也仅有12％的受者仍能维持胰岛素非依赖状态.目前认为,影响临床胰岛细胞移植术后疗效的因素主要包括免疫排斥因素和非免疫排斥因素导致的胰岛损伤、丢失.本文将主要针对胰岛细胞移植术后非免疫排斥因素对其术后疗效的影响,以及胰岛细胞移植术后功能性胰岛细胞的监测方法综述如下.
作者 徐德全 代文杰
机构地区 哈尔滨医科大学附属第一医院甲状腺乳腺细胞移植外科
出处 《国际外科学杂志》 2014年第6期376-379,共4页 International Journal of Surgery
基金 卫生部行业基金项目（No.201302009）
关键词 人胰岛细胞 移植术后 远期疗效 Edmonton方案 胰岛细胞移植术 临床疗效 免疫排斥 术后疗效
分类号 R657.5 [医药卫生—外科学]
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参考文献23

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二级参考文献28

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国际外科学杂志
2014年 第6期

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