心脏辅助装置对急性心力衰竭犬血流动力学的影响

The hemodynamic effects of direct cardiac compression device in acute heart failure dogs

目的 观察心脏辅助装置对于急性心力衰竭（HF,简称心衰）犬血流动力学参数的影响。方法 10条健康犬,体质量25-35 kg,应用冠状动脉（简称冠脉）微栓塞法建立急性心衰模型,对于造模成功的犬采用双心室辅助,并在实验开始时采用1：1的频率辅助,记录主动脉压力、心输出量等血流动力学参数。结果 冠脉微栓塞使心输出量[CO：（2.88±0.38）L/min比（1.58±0.23）I/min]、平均动脉压[MAP：（117.2±9.0）mmHg（1 mmHg=0.133 kPa）比（75.0±6.7）mmHg]等其他血流动力学参数减少（30%-50%）。通过应用心脏直接辅助装置,能提高心输出量[CO：（1.58±0.23）L/min比（2.41±0.34）I/min]和平均动脉压[MAP：（75.0±6.7）mmHg比（103.8±10.0）mmHg],CO和MAP增加20%。收缩压[（93.6±8.03）mmHg比（126.8±7.8）mmHg]、舒张压[（60.4±5.0）mmHg比（87.0±6.1）mmHg]也相应提高,差异有统计学意义（P〈0.05）。辅助前后心率变化不大[（125.4±9.0）次/分比（129.0±10.3）次/分],差异无统计学意义（P〈0.05）。结论 与心脏收缩同步的心脏辅助装置对于急性心衰犬能够改善心脏的收缩能力,辅助心脏的收缩,提高其心输出量,使其血流动力学参数得以提高。

Objective To observe the effects of direct cardiac compression device （DCC） on he- modynamic parameters of acute heart failure in dogs. Methods Ten healthy clean dogs （body weight 25- 35 kg） were used in this study, The coronary micro embolization method was used to establish the acute heart failure model. For the successful models, the biventricular assist was used, with a 1 ： 1 assisted fre quency at the beginning of the experiment. The aortic pressure, cardiac output and other hemodynamic pa rameters were recorded. Results By using coronary micro embolization method, cardiac output （CO） was reduced from （2. 88 ± 0. 38 ） L/rain to （1.58 ± 0. 23 ） L/min and mean arterial pressure （MAP） increased from （75.0 ±6. 7） mmHg （ 1 mmHg =0. 133 kPa） to （ 103.8 ± 10.0） mmHg. The application of direct cardiac assist devices could increase CO [ （ 1.58 ± 0. 23 ） L/min vs. （2.41 ± 0. 34 ） L/rain ] and MAP [ （75.0 ±6. 7） mmHg vs. （ 103.8 ± 10. 0） mmHg] by about 20%. Systolic arterial pressure （SAP） [（93.6±8.03） mmHg to （126.8 ±7.8） mmHg] and diastolic arterial pressure （DAP） [（60.4 ± 5. 0） mmHg to （87. 0 ± 6. 1 ） mmHg] could be increased. The difference was statistically significant in SAP and DAP （ P 〈 0. 05 ）. The heart rate had little change from （ 125.4 ± 9.0 ） to （ 129. 0 ± 10. 3 ） beats/min （P 〉 0. 05 ）. Conclusion Direct cardiac compression device for systolic synchronization of dogs with acute heart failure could improve systolic contractility and increase CO, leading to the improvement of other hemodynamic parameters.