肺动脉高压的流行病学、危险因素和个性化治疗

Patterns, predictors, and personalization in pulmonary arterial hypertension

随着20世纪50年代右心导管检查技术的改进及广泛应用，肺动脉高压的诊断水平明显提高，开启了肺动脉高压现代诊疗及研究的新时代。早期一项人选3例年轻女性肺动脉高压患者的研究发现其平均肺动脉压和肺血管阻力明显升高，而心输出量降低…。早期的研究发现某些特定的心肺疾病可显著影响肺血管，不仅导致右心形态学异常，而且可导致右心输出量下降，这在当时都是革命性的。

Epidemiologic patterns of pulmonary arterial hypertension differ by era and region and may shed light on the pathophysiology and treatment of the disease.New efforts to target one or more of the recently studied therapies could establish personalized medicine as standard care in pulmonary arterial hypertension.