香砂六君子汤对多器官功能障碍综合征之胃肠功能障碍的疗效

Effect of Xiangsha Liujunzi decoction on gastrointestinal dysfunction in patients with multiple organ dysfunction syndrome

目的:探索香砂六君子汤对多器官功能障碍综合征之胃肠功能障碍的影响和临床疗效.方法:对我院近3年来所治疗多器官功能障碍综合征之胃肠功能障碍患者进行研究,依据临床治疗方法分为常规治疗组(52例)和观察组(52例).两组患者均给予常规西医治疗,观察组在常规治疗的方法基础上加用香砂六君子汤治疗,观察两组患者胃黏膜pH、胃动素、白介素-6(interleukin-6,IL-6)等指标和临床症状的改善情况.结果:两组治疗前症状积分、胃黏膜pH、胃动素、IL-6等指标比较,差异无统计学意义(P>0.05).组内比较,治疗3 d与治疗前比较症状积分、胃黏膜pH、胃动素、IL-6明显改善,差异有统计学意义(P<0.05);治疗7 d后症状积分、胃黏膜pH、胃动素、IL-6等指标明显优于治疗前和治疗3 d,差异有统计学意义(P<0.05).组间比较,治疗3 d时各指标组间差异无统计学意义(P<0.05),但观察组较常规治疗组有一定程度改善;治疗7 d时观察组症状积分、IL-6、胃动素、胃黏膜pH明显优于常规治疗组,且组间比较差异有统计学意义(10.8±0.8 vs 13.0±1.0,49.8 pg/mL±6.7 pg/mL vs 61.4 pg/mL±8.8 pg/mL,333.9 pg/mL±12.9 vs 277.1 pg/mL±13.1 pg/mL,7.37±0.02vs 7.32±0.03,P<0.05).结论:香砂六君子汤能有效改善多器官功能障碍综合征之胃肠功能障碍患者胃黏膜pH、胃动素、IL-6等指标和临床症状,值得临床上广泛应用.

AIM： To assess the effect of Xiangsha Liujunzi decoction on gastrointestinal dysfunction in patients with multiple organ dysfunction syndrome. METHODS： Patients with multiple organ dysfunction syndrome who had gastrointestinal dysfunction and were treated at our hospital in the past three years were divided into either a control group （n = 52） or an observation group （n = 52） based on clinical treatment received. All patients received conventional Western medicine treatment, while the observation group was additionally given Xiangsha Liujunzi on the basis of conventional Western medicine treatment. Improvement of gastric pH, motilin, interleukin-6 （IL-6） and other indicators and clinical symptoms were observed and compared. RESULTS： Before treatment, the differences in symptom score, gastric pH, motilin, IL-6 and other indicators between the two groups were not statistically significant （P 〉 0.05）. On the 3rd day of the treatment, gastric pH, motilin, IL-6 and other indicators were improved significantly （P 〈 0.05）. On day 7, the symptom score, gastric pH, motilin, IL-6 and other indicators were significantly better than those before treatment and on day 3 （P 〈 0.05）. On day 3, the indicators showed no significant differences between the two groups （P 〈 0.05）, although a better posi- tive trend could be seen for each indicator in the observation group than in the control group. On day 7, all indicators in the observation group were significantly better than those in the control group （10.8 ± 0.8 vs 13.0 ± 1.0, 49.8 pg/mL ± 6.7 pg/mL vs 61.4 pg/mL ± 8.8 pg/mL, 333.9 pg/mL ± 12.9 pg/mL vs 277.1 pg/mL ± 13.1 pg/ mL, 7.37 ± 0.02 vs 7.32± 0.03, P 〈 0.05）. CONCLUSION： Xiangsha Liujunzi decoction can effectively improve gastric pH, motilin, IL-6 and other indicators as well as clinical symp toms of gastrointestinal dysfunction in patients with multiple organ dysfunction syndrome.