摘要
【目的】探讨半乳糖凝集素-3（galectin-3，GAL-3）在原发性干燥综合征（primary Sjgren＇s syndrome， pSS）及其继发间质性肺病（interstitial lung disease，ILD）发病机制中的作用。【方法】比较73例合并及不合并ILD的pSS患者的临床指标，应用ELISA方法检测73例pSS患者及20例正常对照者血清GAL-3水平。【结果】pSS患者血清 GAL-3水平明显高于正常对照组，且差异有显著性（795．1〈79．3）pg/mL ＆（458．0〈97．4） pg/mL，P＜0．05），而 pSS-ILD患者 Gal-3水平显著高于单纯 pSS患者（1047〈110．7）pg/mL ＆（628．6〈72．62）pg/mL，P＜0．01）。此外，pSS-ILD患者免疫球蛋白 IgG、补体C3、纤维蛋白原（FiB）、C反应蛋白（CRP）及血沉水平明显高于单纯 pSS患者且差异均有显著性（P＜0．05或P＜0．01），血清白蛋白（ALB）则明显低于单纯 pSS患者（P＜0．01）。而且 pSS患者 Gal-3水平与CRP、IgG及 FiB呈正相关关系（r＝0．487，P ＜0．001，r＝0．334，P＝0．004，r＝0．482，P＜0．001）。【结论】半乳糖凝集素-3可能参与pSS的免疫炎症损伤及肺间质纤维化的发生发展。
[Obj ective]To explore the role of galectin-3 （GAL-3 ）in pathogenesis of primary Sjgren＇s syn-drome（pSS）patients with interstitial lung disease（ILD）.[Methods]Clinical indexes of 73 pSS patients with and without ILD were compared.Enzyme linked immunosorbent assay（ELISA）was used to detect serum levels of GAL-3 in 73 pSS patients and 20 normal controls.[Results]Serum GAL-3 levels in pSS patients were obviously higher than those in normal controls,and there was significant difference（795.1〈79.3pg/mL vs.458.0±97.4 pg/mL,P〈0.05）.Serum GAL-3 levels in pSS-ILD patients were markedly higher than those in simple pSS pa-tients（1047〈110.7 pg/ml vs.628.6〈72.62 pg/ml,P〈0.01）.Furthermore,the levels of IgG,C3,fibrinogen （FiB）,acute phase reactive protein（CRP）and blood sedimentation in pSS-ILD patients were obviously higher than those in simple pSS patients,and there was significant difference（P〈0.05 or P〈0.01）.Serum albumin（ALB） levels in pSS-ILD patients were obviously lower than those in simple pSS patients（P〈0.01）.Serum GAL-3 lev-els in pSS patients were positively correlated with CRP,IgG and FiB（r=0.487,P 〈0.001,r= 0.334,P =0.004,r=0.482,P〈0.001）.[Conclusion]GAL-3 may participate in immune inflammatory injury of pSS and the occurrence and development of ILD.
出处
《医学临床研究》
CAS
2014年第6期1059-1061,1064,共4页
Journal of Clinical Research
基金
辽宁省科学技术计划项目（2012225097）,中国医科大学第一附属院科研课题（fsfh1212）
