不同细胞因子在重症肺炎诊断中的临床意义

Clinical Significance of Different Cytokines in the Diagnosis of Severe Pneumonia

【目的】探讨不同细胞因子在重症肺炎患者临床诊断中的意义。【方法】收集肺炎患者100例，根据患者病情将其分为重症肺炎组40例、普通肺炎组60例；另选取健康体检者50例作为对照组，检测并比较三组患者白细胞介素-6（IL-6）、白介素-8（IL-8）、肿瘤坏死因子（TNF）、C-反应蛋白（CRP）及白细胞（WBC）水平。【结果】重症肺炎组血清细胞因子TNF、IL-6、IL-8、CRP及WBC水平均显著高于普通肺炎组及对照组，且普通肺炎组显著高于对照组，其差异均有统计学意义（P〈0．05）。【结论】血清细胞因子TNF、IL-6、IL-8的升高对重症肺炎患者的诊断具有一定意义。

[Objective] To explore the significance of different cytokines in clinical diagnosis of patients with severe pneumonia. [Methods]Totally 100 patients with pneumonia were collected. According to the patient＇s condition, all patients were divided into severe pneumonia group（ n = 40） and common pneumonia group （ n =60）. Other 50 healthy subjects were selected as control group. The levels of interleukin-6（IL-6）, inter- leukin-8（IL-8）, tumor necrosis factor （TNF）, C-reactive protein （CRP） and white blood cell （WBC） were measured and compared among 3 groups. [Results] The levels of serum cytokines TNF, IL-6, IL-8, CRP and WBC in severe pneumonia group were markedly higher than those in common pneumonia group and control group, and those in common pneumonia group were markedly higher than those in control group, and there were significant differences（ P 〈0.05）. [Conclusion] The increasing of serum cytokines TNF, IL-6, IL-8 is of certain significance in the diagnosis of patients with severe pneumonia.