舍曲林合并喹硫平治疗难治性抑郁症的疗效观察

Observation of effects of Sertraline combined with Quetiapine in treatment of refractory depression

目的:探讨舍曲林合并喹硫平治疗难治性抑郁症的疗效及安全性。方法:将80例难治性抑郁症患者随机分为两组,分别给予舍曲林合并喹硫平(研究组)和单用舍曲林(对照组)治疗8周。于治疗前和治疗1、2、4、8周以汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)分别评定疗效,用副反应量表(TESS)评定不良反应。结果:舍曲林合并喹硫平治疗难治性抑郁症的疗效要明显优于单一使用舍曲林治疗,两组患者的不良反应均较小。结论:舍曲林联合喹硫平治疗难治性抑郁症的疗效明显,安全性好。

Objective：To explore the effects and safety of Sertraline combined with Quetiapine in treatment of refractory depres-sion. Methods：A total of 80 patients with the refractory depression were randomly divided into Sertraline combined with Quetiapine group （study group） and Sertraline group （control group）, and they were treated for 8 weeks. All patients were evaluated with Hamil-ton depression scale （HAMD）, Hamilton anxiety scale （HAMA） and treatment emergent symptom scale （TESS） before the treatment and at the end of the first, second, forth and eighth week of the treatment for the effects and adverse reactions, respectively. Results：The therapeutic effect of Sertraline combined with Quetiapine was significantly better than that of Sertraline. The adverse reactions in the two groups were fewer. Conclusions： Sertraline combined with Quetiapine is an efficacious and safe strategy in the treatment of re-fractory depression.