VEGF在妊娠期糖尿病产妇分娩新生儿脐血中的表达研究

A study on VEGF expression in umbilical blood of newborns delivered by mothers with gestational diabetes

目的探讨VEGF在妊娠期糖尿病产妇分娩新生儿的脐静脉血及动脉血中的表达及价值。方法对80例妊娠期糖尿病产妇分娩的新生儿及80例健康产妇分娩的新生儿的脐静脉和动脉血的VEGF水平进行放射免疫分析检测。结果观察组新生儿的脐动脉血VEGF水平为(24.06±8.79)pg/mL,脐静脉血VEGF水平为(20.69±7.78)pg/mL,均显著高于对照组;同时,观察组低血糖新生儿脐动脉血的VEGF水平显著高于对照组及观察组血糖正常的新生儿。结论妊娠期糖尿病产妇分娩新生儿的脐静脉和动脉血的VEGF水平明显高于健康产妇分娩的新生儿,新生儿脐动脉血的VEGF水平可以在一定程度上反映出妊娠期糖尿病对于胎儿的影响。

Objective To investigate the expression and value of vascular endothelial growth factor（VEGF）in umbilical venous and arterial blood in newborns delivered by gestational diabetic mothers.Methods The umbilical venous and arterial blood from 80 newborns delivered by gestational diabetic parturients and 80 newborns delivered by healthy parturients were collected for detecting the VEGF level by the radioimmunoassay method.Results The VEGF level of the umbilical arterail blood in the observation group was （24.06±8.79）pg/mL,which of umbilical venous blood was （20.69 ±7.78）pg/mL,all were significantly higher than that in the control group;at the same time the VEGF level of the umbilical arterial blood in hypoglycemia newborns of the observation group was significantly higher than that in the normal blood glucose newborns of the control group and the observation group.Con-clusion The umbilical vein and arterial blood VEGF level in the newborns delivered by gestational diabetic parturients is signifi-cantly higher than that in the newborns delivered by healthy parturients,the VEGF level of neonatal umbilical arterial blood can re-flects the influence of gestational diabetes on fetus to some extent.