2型糖尿病患者合并非酒精性脂肪肝的临床观察

Analysis of clinical characteristic of non-alcoholic fatty liver disease in patients with Type 2 diabetes mellitus

目的:观察2型糖尿病患者(T2DM)合并非酒精性脂肪肝(NAFLD)的临床特点,分析T2DM合并NAFLD的危险因素。方法:选取138例住院的T2DM患者,分别测量血压、身高、体重,计算体质指数(BMI);同时测定空腹血糖(FPG)、餐后2小时血糖(2hPG)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、空腹胰岛素(FINS)及餐后2小时胰岛素(PINS)。所有对象依B超检查结果是否脂肪肝分为NAFLD组(54例)和非脂肪肝(NFLD)组(84例)。对两组相关指标进行对比分析。结果:T2DM中NAFLD的患病率为39.2%,NAFLD组血清肝酶水平升高者为69.23%;T2DM合并NAFLD组患者BMI、TG、FINS、PINS水平明显升高(P<0.05或P<0.01)。结论:T2DM患者中NAFLD呈现较高的患病率;BMI、TG、FINS、PINS可能是T2DM合并NAFLD的主要危险因素。

To investigate the clinical characteristic of non-alcoholic fatty liver disease with type 2 diabetes mellitus , and to analysis its risk factors . Method：138 patients with T2DM were selected . Biochemical tests and liver ultrasound examination were retrieved. Biochemical indices between T2DM patients with and without NAFLD （NAFLD and NFLD） were compared . Results：The prevalence of NAFLD in T2DM patients was 39 . 2%, among which 69 . 23% had the elevated liver enzymes . Compared with NFLD group , the BMI , triglycerid , FINS , PINS and ALT , AST in NAFLD group were significantly higher （P〈0 . 05 or P〈0 . 01）. Conclusion：There is high prevalence of NAFLD in patients with type 2 diabetes mellitus . BMI , TG , FINS and PINS were major risk factors for T2DM patients with NAFLD .