5-氨基酮戊酸光动力疗法与物理疗法治疗尿道尖锐湿疣的系统评价

Efficacy of Photodynamic Therapy and Physical Therapy for Patients with Condyloma Acuminatum:A Systematic Review

目的:系统评价5-氨基酮戊酸光动力疗法(ALA-PDT)与常规物理疗法治疗尿道尖锐湿疣的临床疗效及安全性。方法:通过计算机检索系统检索有关ALA-PDT与物理疗法(CO2激光、冷冻、电灼)治疗尿道尖锐湿疣疗效的公开发表文献,并行Meta分析。结果:Meta分析显示ALA-PDT较常规物理疗法能明显降低尿道尖锐湿疣复发率,ALA-PDT与CO2激光、冷冻、电灼比较相对危险度(RR)分别为0.22,0.24,0.26;能降低治疗后不良反应发生率,ALA-PDT与CO2激光、电灼比较RR分别为0.30,0.12;但疣体清除率不如CO2激光、电灼,RR分别为0.97,0.95。结论:ALA-PDT可有效防止尿道尖锐湿疣复发并具有较好的安全性,但清除率不如物理疗法。

To determine whether 5-amino-ketovaleric acid photodynamic（ALA-PDT） and physical therapy was an effective strategy in the treatment of patients with condyloma acuminatum （CA）. Methods： Clinical literature about ALA-PDT and physical therapy （CO2 laser , liquid nitrogen freezing , electrocautery） were reviewed and identified for meta-analysis . Results： the meta-analysis showed ALA-PDT could lower the recurrence rate and adverse reaction of CA , Significant differences were found between ALA-PDT group and physical therapy group . Conclusion： ALA-PDT can decrease the recurrence rate of CA and improve the effect of patients with CA , but have a lower cure rate than physical therapy .