摘要
发展了一种以PdBr2为催化剂,以[Bmim]X/HXaq为溶剂,炔卤与5-己烯-1-醇进行交叉偶联反应的新方法,以中等及优良的产率(73%~94%)合成了系列cis-1,2-二卤代-1,7-辛二烯衍生物.反应表现出较高的区域选择性和立体选择性.并且该偶联反应合成途径简捷、反应条件温和,可为cis-1,2-二卤代烯烃类化合物的合成提供简便的途径.
A Pd-catalyzed method was developed for cross-coupling reaction of a wide range of haloalkynes with hex-5-en-1-ol in ionic liquids. In the presence of PdBr2, [Bmim]X and HXaq, the cross-coupling products can be obtained in moderate to good yields, and the reaction displayed high regio- and stereo-selectivities. Moreover, the reaction is a convenient and simple path for the synthesis of the cis-1,2-dihalosubstituted alkenes, and tolerates several functional groups on haloalkynes.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2014年第6期1148-1153,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21102047
31101221)
华南理工大学学生研究计划资助项目~~