离子液体中钯催化合成cis-1,2-二卤代-1,7-辛二烯的反应研究

Synthesis of cis-1,2-Dihalosubstituted 1,7-Octadienes by Pd-Catalyzed Cross-Coupling Reaction in Ionic Liquids

发展了一种以PdBr2为催化剂,以[Bmim]X/HXaq为溶剂,炔卤与5-己烯-1-醇进行交叉偶联反应的新方法,以中等及优良的产率（73%～94%）合成了系列cis-1,2-二卤代-1,7-辛二烯衍生物.反应表现出较高的区域选择性和立体选择性.并且该偶联反应合成途径简捷、反应条件温和,可为cis-1,2-二卤代烯烃类化合物的合成提供简便的途径.

A Pd-catalyzed method was developed for cross-coupling reaction of a wide range of haloalkynes with hex-5-en-1-ol in ionic liquids. In the presence of PdBr2, [Bmim]X and HXaq, the cross-coupling products can be obtained in moderate to good yields, and the reaction displayed high regio- and stereo-selectivities. Moreover, the reaction is a convenient and simple path for the synthesis of the cis-1,2-dihalosubstituted alkenes, and tolerates several functional groups on haloalkynes.