有机碱催化的H-亚磷酸酯与靛红及其衍生物的phospho-Aldol-Brook重排串联反应

Organic Base Catalyzed Cascade Phospho-Aldol-Brook Rearrangement Reaction of Isatins with H-phosphonates

在温和的反应条件下,以1,1,3,3-四甲基胍(TMG)或1,8-二氮杂二环[5.4.0]十一碳-7-烯(DBU)有机碱作为催化剂,催化H-亚磷酸酯与靛红的phospho-Aldol-Brook重排串联反应,高效、高产率合成了两个系列α-羟吲哚基-磷酸酯类化合物.

A cascade phospho-aldol-Brook rearrangement reaction of isatins with H-phosphonates was reported by the use of the organic base, such as 1,1,3,3-tetramethylguanidine（TMG） or 1,8-diazabicyclo[5.4.0]undec-7-ene（DBU）, as an organocatalyst. Two series of 2-oxoindolin-3-yl phosphates were obtained in good to excellent yields under mild reaction conditions.