老年肥胖高血压患者白介素-18、-10水平及其比值变化的临床意义

The clinical significance of IL-18,IL-10 and IL-18/IL-10 changes in aged patients with obesity and hypertension

目的探讨老年肥胖高血压患者血浆白细胞介素-18(IL-18)、白细胞介素-10(IL-10)及其比值的变化和临床意义。方法纳入116例老年肥胖高血压患者(实验组)和116例老年非肥胖高血压患者(对照组),检测两组患者血脂、血糖、胰岛素,计算胰岛素抵抗指数,采用酶联免疫吸附(ELISA)法检测其血清IL-18、IL-10等浓度变化。结果老年肥胖高血压患者胰岛素抵抗指数、血浆IL-18、IL-10水平及其比值明显高于老年非肥胖高血压患者(P<0.01或P<0.05)。结论老年肥胖高血压患者血浆IL-18升高,IL-18与抗炎因子IL-10比例失调,可能加重老年肥胖高血压患者动脉粥样硬化的进展过程。

Objective To investigate the changes of plasma interleukin-18（IL-18）,interleukin-10（IL-10）and IL-18/IL-10 ratio in aged patients with obesity and hypertension and the clinical significance.Methods 116 aged patients with obesity and hypertension and 116sex and age matched controls（aged patients with hypertension but not obesity）were enrolled in the study.Blood lipid,glucose and insulin were investigated and the insulin resistance index was calculated.Plasma IL-18 and IL-10 concentrations were measured by enzyme-linked immunosorbent assay（ELISA）.Results The insulin resistance index,plasma IL-18,IL-10 and IL-18/Il-10 ratio in aged patients with obesity and hypertension were significantly higher than that in control subjects（P〈0.01or P〈0.05）.Conclusion The elevation of IL-18 and IL-18/Il-10 ratio may accelerate the process of atherosclerosis in aged patients with obesity and hypertension.