安神定悸汤治疗早搏的临床研究

Clinical Observation on Anshen Dingji Decoction for Treatment of Premature Contractions

目的观察安神定悸汤治疗心阳不振和/或气阴两虚证型早搏的临床疗效。方法将中医辨证符合要求证型的80例患者随机分为治疗组(安神定悸汤治疗组)和对照组(参松养心胶囊治疗组),治疗4周。观察两组患者心电图、动态心电图,中医症状,早搏发作次数、程度、持续时间等变化。结果中医证候疗效:治疗组总有效率为97.5%,对照组总有效率为87.5%,治疗组优于对照组(P<0.05)。对不同种类早搏的心电图疗效方面:治疗组对心阳不振和/或气阴两虚证型房性早搏、交界性早搏、室性早搏、房早合并室性早搏疗效分别为92.3%、75.0%、94.1%、66.7%,对照组对4种不同类型早搏疗效分别为85.7%、60.0%、87.5%、20.0%。两组各型早搏组间比较差异无统计学意义(P>0.05)。两组总疗效相比较差异无统计学意义(87.5%vs77.5%,P>0.05)。结论安神定悸汤治疗心阳不振和/或心气阴两虚型早搏,与参松养心胶囊比较,症状改善较明显,而对不同种类早搏的心电图改善、总疗效相当。

Objective To observe the effect of Anshen Dingji decoction（ADD）on premature contraction with heart-yang hypofunction syndrome or deficiency syndrome of qi and yin.Methods Eighty premature contraction patients with heart-yang hypofunction or deficiency syndrome of qi and yin were randomly divided into two groups：The control group treated with Shensong Yangxin capsule（SYC）and the treatment group treated with ADD for 4weeks.Electrocardiogram（ECG）and ambulatory electrocardiogram were conducted before and after the treatment.Traditional Chinese Medicine（TCM）symptoms,tongue signs,and pulse were observed.Results The total clinical effective rate of TCM symptoms was 97.5%in treatment group,which was significantly higher than that in control group（87.5%,P〈0.05）.The effective rate of atrial premature contractions（APCs）,junctional premature contractions,premature ventricular contractions（PVCs）,APCs complicated by PVCs was 92.3%,75.0%,94.1%,and 66.7% respectively in treatment group,and that was 85.7%,60.0%,87.5%,and 20.0% respectively in control group.There was no difference between two groups（P〉0.05）.Conclusion ADD could improve TCM symptoms in premature contraction patients with heart-yang hypofunction syndrome or deficiency syndrome of qi and yin.