美罗培南治疗老年重症院内获得性肺炎的疗效分析

Analysis of meropenem in the treatment of elderly patients with severe hospital acquired pneumonia

目的探讨美罗培南在治疗老年重症院内获得性肺炎中的疗效。方法随机选取我科老年重症肺炎患者189例,其中73例作为病例组采用美罗培南静脉注射治疗,美罗培南治疗方法和剂量为静脉滴注500 mg/次,每日3次;而116例设为对照组,使用亚胺培南-西司他丁静脉滴注500 mg/次,每日4次。疗程均为7～10 d。分析两组的临床疗效、细菌清除情况、不良反应。结果治疗组总有效率82.19%,细菌清除率87.93%,不良反应发生率5.48%;对照组总有效率为62.93%,细菌清除率68.35%,不良反应发生率6.03%。美罗培南组总有效率、细菌清除率均高于对照组,差异均有统计学意义（P〈0.05）。结论美罗培南更适用于老年重症院内获得性肺炎、老年重症感染、和或伴有中枢神经精神症状者的患者。

Objective To investigate the efficacy of meropenem in the treatment of elderly patients with severe hospital acquired pneumonia. Methods 189 elderly patients with severe pneumonia were randomly divided into two groups. The treatment group was given intravenous injection with meropenem,500 mg /once,three times a day.The control group was given imipenem cilastatin intravenous,500 mg /once,four times a day. The clinical curative effect was evaluated between the two groups. Results The total effective rate of the treatment group was 82. 19%,the bacterial clearance rate was 87. 93%,and the incidence of adverse reaction was 5. 48%. The total effective rate was 62. 93% in the control group,the bacterial clearance rate was 68. 35%,and the incidence of adverse reaction was 6. 03%. Conclusion Meropenem is more suitable for the elderly patients with severe hospital-acquired pneumonia,and severe infection associated with central nervous mental symptoms.