血清C反应蛋白检测在小儿支原体肺炎诊断中的临床价值

Clinical value of detection of serum C-reactive Protein in the diagnosis of children with mycoplasmal pneumonia

目的探讨血清C反应蛋白(CRP)检测在小儿支原体肺炎(MP)诊断中的价值。方法 128例肺炎患儿按照病原体的不同分为支原体组(45例)、细菌组(43例)、病毒组(40例),并选择健康体检儿童40例作为对照组,比较治疗前四组研究对象血清CRP水平和检测阳性率,并比较不同病情程度MP患儿血清CRP水平和检测阳性率,治疗1周后,比较3组患儿血清CRP水平和检测阳性率。结果血清CRP水平和检测阳性率组间比较,细菌组均明显高于其他3组(P=0.0000),支原体组明显高于病毒组和对照组(P=0.0000),病毒组与对照组比较差异无显著性(P>0.05)。支原体肺炎患儿中伴有全身炎症反应组血清CRP水平和阳性率均高于不伴有全身炎症反应组。治疗1周后,支原体组血清CRP水平高于病毒组(P=0.000),低于细菌组(P=0.0000),CRP检测阳性率支原体组高于病毒组(P=0.0041),低于细菌组(P=0.0223)。结论血清CRP水平检测可作为MP早期诊断和鉴别诊断的重要手段。

Objective To explore the clinical value of detection of serum C-reactive protein in the diagnosis of children with mycoplasmal pneumonia. Methods 128 patients with pneumonia were randomly divided into the mycoplasma group（ 45 cases）,the bacterial group（ 43 cases）,and the virus group（ 40 cases） according to different pathogens,and 40 healthy children were selected as the control group. The level of serum CRP and the positive detection rate of the four groups were compared 1 week after the treatment. Results The level of serum CRP and the detection positive rate in the bacterial group were significantly higher than the other three groups（ P = 0. 0000）,and the mycoplasma group was significantly higher than the virus group and the control group（ P = 0. 0000）. There was no significant difference between the virus group and the control group（ P〉0. 05）. The level of serum CRP and the positive rate were associated with systemic inflammation. The level of serum CRP of the mycoplasma group was higher than that of the virus group at 1st week after treatment（ P = 0. 000） and lower than that of the bacteria group（ P =0. 0000）. The positive detection rate of CRP of the mycoplasma group was higher than that of the virus group（ P =0. 0041） and lower than that of the bacteria group（ P = 0. 0223）. Conclusion The detection of serum CRP can be used as an important means in the diagnosis of early MP.