晚期实体肿瘤患者凝血指标的变化及其临床意义

Study on changes and clinical significance of coagulation parameters in patients with advanced solid tumors

目的探讨晚期实体肿瘤患者凝血功能的变化。方法采集71例晚期实体肿瘤患者(晚期肿瘤组)与20例健康人(对照组)的静脉血,检测血小板、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D-二聚体(D-Dimer)和纤维蛋白原(Fbg)。结果晚期肿瘤组血小板数值较对照组明显升高,两组比较有显著性差异(P<0.01)。晚期肿瘤组较对照组Fbg、D-Dimer显著升高(P<0.01),APTT显著缩短(P<0.05)。结论晚期实体肿瘤患者存在高凝状态,正确的抗凝治疗是必要的。

Objective To clarify the changes of coagulation function in patients with advanced solid tumors. Methods A total of 71 patients with advanced solid tumors and 20 healthy persons as controls were collected. Platelet count,prothrombin time（ PT）,activated partial thromboplastin time（ APTT）,D-Dimer and fibrinogen（ Fbg） were detected. Results There was significantly increase of platelets in advanced solid tumors group compared to those of healthy control group; there was significant elevation of Fbg and D-Dimer and significantly shortened APTT in advanced solid tumors group compared to those of healthy control group. Conclusion Patients with advanced solid tumors exist in hypercoagulable status and appropriate anticoagulation therapy should be applied.