阿托伐他汀对急性ST段抬高型心肌梗死患者尿激酶溶栓疗效

Effect of the thrombolytic therapy of acute ST segment elevation myocardial infarction patients by Atovatatin

目的探讨阿托伐他汀对急性ST段抬高型心肌梗死患者尿激酶溶栓疗效。方法分析同济大学附属同济医院2008年1月～2013年12月收治的60例急性ST段抬高型心肌梗死患者临床资料,依据治疗措施不同进行临床分组,常规治疗组（通过常规的溶栓治疗）30例和观察组（在常规溶栓前给予阿托伐他汀）30例。观察两组患者治疗前后超敏C反应蛋白（hs-CRP）、白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）变化情况,观察两组患者胸痛缓解时间、ST段回落、酶峰出现时间和再灌注心律失常情况。结果两组治疗前hs-CRP、IL-6和TNF-α比较差异无统计学意义（t=0.23、0.20、0.17,均P〉0.05）,观察组治疗后hs-CRP、IL-6和TNF-α均优于常规治疗组（t=3.81、33.00、23.08,均P〈0.05）,观察组胸痛缓解时间、ST段回落、酶峰出现时间和再灌注心律失常均优于常规治疗组,差异均有统计学意义（t=2.45、3.04、3.01、4.90,均P〈0.05）。结论阿托伐他汀在急性ST段抬高型心肌梗死患者中的应用可以提高患者尿激酶溶栓治疗效果,降低复发率,值得临床推广应用。

Objective To investigate the effect of the thrombolytic therapy of acute ST segment elevation myocardial infarction patients by Atovatatin. Methods The clinical data of 60 cases of patients with acute ST segment elevation myocardial infarction admitted to Tongji Hospital Affiliated to Tongji University was analyzed, according to different treating methods, the patients were divided into two groups, 30 cases of conventional treatment group（through conventional thrombolysis treatment） and 30 cases of observation group（in conventional Atorvastatin before thrombolysis）. The hs-CRP, IL-6 and TNF-α before and after treatment of two groups were detected. The chest pain relief time, ST-segment resolution, enzyme peak appearing time and reperfusion arrhythmia of two groups were detected. Results The hsCRP, IL-6 and TNF-α before treatment of two groups were not statistically different（t = 0.23, 0.20, 0.17, P〉0.05）,hs-CRP, IL-6 and TNF-α after treatment of observation group were better than conventional treatment group（t = 3.81,33.00, 23.08, P〈0.05）. The chest pain relief time, ST-segment resolution, enzyme peak appearing time and reperfusion arrhythmia observation group acute ST segment elevation myocardial infarction patients were better than conventional treatment group, the differences were statistically significant（t = 2.45, 3.04, 3.01, 4.90, all P〈0.05）. Conclusion The effect of urokinase thrombolysis treatment acute ST segment elevation myocardial infarction patients by Atovatatin is improved, recurrence rate is decreased, which is worthy to be used in clinic.