Ⅱ型胶原降解产物C2C对骨关节炎早期诊断与社区筛查的研究进展

Research progress of the early diagnosis and community scanning of type 2 collagen biomarker C2C in osteoarthritis

骨关节炎(osteoarthritis,OA)是老年人群中最常见的关节疾病。如何早期诊断关节软骨损伤成为目前OA研究的重点和难点。软骨的主要组成是Ⅱ型胶原,所以其合成和降解所产生的生物学标志物已成为研究重点。对关节滑液、血清、尿中的生物学标志物的检测可以早期诊断疾病、监测疾病的发展、了解机体对治疗药物的反应。

Osteoarthritis （OA） is the most common joint disease in the ageing population. How to establish the early diagnosis of articular cartilage injury has become the important and difficult points now. The major component of cartilage is collagen type 2, so the biological markers produced in the synthesis and degradation have become a research focus. The biomarkers detecting in the synovial fluid, serum and urine can achieve the early diagnosis and monitoring the development of the disease, and understand the body＇s response to the drug treatment.