氟化钠对奶山羊血清激素含量的影响

Effect of sodium fluoride on hormones levels in blood serum of milk goat

以奶山羊为试验动物 ,按体重灌服氟化钠 ,复制奶山羊氟病模型 ,通过甲状腺功能指标、骨代谢调节因子等一系列指标的测定 ,进一步探讨了氟病的发生机理。研究结果表明 ,氟引起甲状腺激素合成和分泌障碍及甲状腺调节因子紊乱 ,呈现甲状腺机能减退的症状 ,进而影响了机体的新陈代谢等过程 ;氟导致骨代谢调节因子骨钙素和降钙素含量升高 。

Twelve milk goats were divided into two study groups.GroupⅠ was treated as control and groupⅡwere fed sodium fluoride(NaF) orally according to their bodyweights. After 12 months of fluoride dosing, goats of groupⅡshowed clinical signs of fluorosis and blood samples were taken for analysis.The results showed that fluoride disturbs the synthesis and secretion of throid hormone,and interferes with the regulatory system of thyroid. The contents of modulate factors in bone metabolism,including calicitonin and osteocalcin rose in groupⅡ.The result showed that the skeletal fluorosis is characterized by highly bone turning over .Fluoride can effect bone modeling and increases bone mass.