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造血干细胞移植术后继发T淋巴母细胞淋巴瘤一例并文献复习

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摘要 目的 了解移植后淋巴组织增生性疾病（PTLD）的临床特点、治疗及预后.方法 对1例资料完整的T细胞性PTLD患者的临床特点、治疗及生存情况进行回顾性分析.结果 该患者最初表现为广泛的慢性皮肤移植物抗宿主病（GVHD）,加强抗排斥药物后,GVHD症状好转.后出现右下眼睑肿物,伴右侧颌面部肿胀、麻木感.64排CT示：右侧筛窦、额窦占位性病变,右侧眶周及眶底占位性病变.局部肿物病理活组织检查结果示：T淋巴母细胞性非霍奇金淋巴瘤.给予CHOP联合门冬酰胺酶方案化疗,肿物明显缩小,疗效评价为部分缓解（PR）.后给予化疗结合局部放疗,评价仍为PR.诊断PTLD后14个月死于肺部感染.结论 T细胞性PTLD治疗效果普遍很差,早期诊断及探索更有效的安全防治措施是需要解决的关键问题.
作者 袁晓莉 刘秋雨 张茵 朱尊民
机构地区 河南省人民医院血液科 河南省人民医院病理科
出处 《白血病．淋巴瘤》 CAS 2014年第6期371-373,共3页 Journal of Leukemia & Lymphoma
关键词 移植后淋巴组织增生性疾病 造血干细胞移植 治疗
分类号 R733.1 [医药卫生—肿瘤]
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白血病．淋巴瘤
2014年 第6期

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