摘要
目的建立顶空气相色谱法测定达托霉素中有机溶剂乙醇、乙腈含量的方法。方法以DB-WAX毛细管柱为分离柱,采用程序升温,检测器为FID。结果线性关系良好,方法精密度、重复性均符合要求。结论该方法可用于达托霉素原料中残留溶剂乙醇和乙腈的含量测定。
Objective To establish a method for the determination of residual ethanol and acetonitrile in daptomycin by headspace gas chromatography.Methods The DB-WAX capillary column was adopted,temperature programming and FID detector was used.Results The two compositions had good linear relationship and the precision and reproducibility of the method were in accord with the requests.Conclusion This method could be used to determine residual ethanol and acetonitrile in daptomycin.
出处
《药学研究》
CAS
2014年第7期389-390,410,共3页
Journal of Pharmaceutical Research
关键词
顶空气相色谱法
达托霉素
溶剂残留量
测定
Headspace gas chromatography
Daptomycin
Residual solvents
Determination
