不同类型血吸虫病患者血小板参数的对比研究

Changes and clinical significance of platelet parameter in patients with different types of schistosomiasis

目的探讨不同诊断类型血吸虫病患者血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT)四项参数的变化及其临床意义。方法采用全自动血细胞分析仪及其配套试剂检测68例慢性血吸虫病患者(以下简称"慢血")、76例晚期血吸虫病患者(以下简称"晚血",其中巨脾型52例、腹水型24例)以及78例健康对照组的外周血PLT、MPV、PDW、PCT。结果慢血组和晚血组PLT、PCT均明显低于健康对照组(P<0.01),其中晚血组随着病情的进展,肝纤维化程度加深甚至出现肝硬化,其MPV、PDW也发生变化,明显高于对照组,差异有统计学意义(P<0.01)。结论检测血小板各项参数值,可为血吸虫病患者特别是晚血患者病情诊断提供初步评价,对指导临床治疗及判断病人预后有重要意义。

Objective To investigate the changes and clinical significance of Platelet count （PLT）, mean platelet volume （MPV）, platelet distribution width （PDW）, and platelet hematocrit （PCT） in patients with different types of schistosomiasis. Methods PLT, MPV, PDW and PCT of 68 patients with chronic schistosomiasis （CS）, 76 cases with advanced schistosomiasis （AS, involved 52 cases of splenomegaly type and 24 cases of ascites type） and 78 cases of healthy people were detected by automatic hematology analyzer and reagents. Results The PLT and PCT of CS and AS groups were significantly lower than the healthy people （P〈0.01）. With the progress of the disease, the degree of liver fibrosis deepened and even hepatocirrhosis occurred in AS group and their MPV and PDW were significantly higher than the healthy people （ P〈0.01）. Conclusion It can provide a preliminary evaluation of the patients ’condition with schistosomiasis, especially advanced schistosomiasis, and guide the clinical treatment and determine the prognosis of patients by detecting various parameter values of platelet.