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Clusterin在庆大霉素诱导的急性肾损伤大鼠模型中的表达及诊断意义

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摘要 Clusterin 是体内一种异二聚体糖蛋白,最初见于公羊睾丸液,作用为促细胞聚集。其后陆续研究发现 Clusterin 参与许多重要生理过程:细胞周期调控、DNA 的损伤修复和组织修复等,具有辅助生殖、脂质转运、抑制补体介导的细胞免疫等功能[1],还与调控细胞凋亡有关[2]。
机构地区 吉林大学药学院
出处 《中国实验诊断学》 2014年第7期1072-1073,共2页 Chinese Journal of Laboratory Diagnosis
基金 吉林省科技发展计划资助项目(科技支撑计划20120962) 吉林大学开放性创新实验项目(2013B73337) 吉林省卫生厅资助项目(2013Z101)
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参考文献7

  • 1邹颖刚,王欢,耿嘉男,印悦,石艳,于晓艳.Clusterin在急性肾损伤诊断中的意义[J].中国实验诊断学,2013,17(5):982-982. 被引量:6
  • 2Prochnow H, Gollan R, Rohne P, et al. Non Secreted Clusterin Isoforms Are Translated in Rare Amounts from Distinct Human mRNA Variants and Do Not Affect Bax-Mediated Apoptosis or the NF-κB Signaling Pathway[J]. PloS one,2013,8(9) :e75303.
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二级参考文献23

  • 1王贵宪,文建国,武玉东,李春凌,Forkiaer.J.幼鼠双侧输尿管梗阻后肾脏钠通道NHE3和TSC的变化[J].中华小儿外科杂志,2005,26(1):42-45. 被引量:1
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  • 9Rosenberg ME, Girton R, Finkel D, et al. Apolipoprotein clusterin prevents a progressive glomerulopathy of aging [J].Mol Cell Bi- ol,2002,22(6) : 1893.
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