清金益气汤加减治疗晚期非小细胞肺癌气阴两虚型临床观察

Effect of Qingjinyiqi Decoction on Advanced Non-small Cell Lung Cancer with TCM Differentiation Syndrome of Qi-yin Deficiency

目的观察清金益气汤治疗晚期非小细胞肺癌气阴两虚型的临床疗效。方法 59例晚期非小细胞肺癌患者随机分成治疗组30例和对照组29例,对照组单纯使用GP方案化疗2个周期,治疗组在化疗基础上连续服用清金益气汤,观察两组癌瘤病灶变化、中医症状、体力状况及生存情况。结果两组肿瘤病灶均有缩小,治疗组疾病控制率50.0%,对照组为31.0%,两组比较差异有统计学意义(P<0.05);两组患者生存质量和中医临床证候均明显改善,治疗组明显优于对照组(P<0.05)。随访结束时治疗组中位无进展时间7.2个月,中位生存时间11.5个月,对照组为5.7个月和8.6个月,差异有统计学意义(P<0.01)。结论清金益气汤联合化疗治疗晚期非小细胞肺癌气阴两虚型,对提高患者无进展时间及中位生存时间具有明显优势。

Objective To investigate the effect of Qingjinyiqi decoction on patients with advanced non-small cell lung cancer（NSCLC） with TCM syndrome of Qi-yin deficiency. Methods Fifty-nine patients with advanced NSCLC with TCM syndrome of Qi-yin deficiency were randomly divided into treatment group（n=30） and control group（n=29）. Patients in control group received GP chemotherapy（gemcitabine＋DDP） for 2 courses. Patients in treatment group received GP therapy plus Qingjinyiqi decoction. Changes of malignant lesions,TCM symptoms, physical conditions,and survival rate were observed and compared between two groups. Results Tumor was reduced in both groups after treatment,with disease control rate of 50.0% in treatment group and of 31.0% in control group （P〈0.05）;quality of life and TCM symptoms in patients from both groups were improved and more effect was seen in treatment group （P〈0.05）. By the end of follow up, the progression-free survival time and medium survival time were 7.2 and 11.5 in treatment group,respectively and were 5.7 and 8.6 in control group,respectively,with significant differences between two groups（P〈0.01）. Conclusion Qingjinyiqi decoction combined with GP chemotherapy may have advantages on enhancing the progression-free survival time and medium survival time of patients with advanced NSCLC with TCM syndrome of Qi-yin deficiency.