肺肠同治指导下中医药对柳氮磺胺吡啶灌肠治疗溃疡性结肠炎增效解毒研究

Study on Synergistic Effect and Detoxification on Regulation of Chinese Medicine to SASP Enema Under Guidance of Synchronous Treatment of Lung and Intestine

目的:通过肺肠同治方药对柳氮磺胺吡啶(SASP)在溃疡性结肠炎(UC)灌肠治疗中的增效解毒作用揭示,证明该治法理论的科学性。方法:60例中医诊断为热毒炽盛证,西医诊断为UC的患者随机分为3组:对照组、治肠组、肺肠同治组,每组各20例,分别采单纯SASP灌肠(对照组),白头翁汤、调胃承气汤配合SASP灌肠(治肠组),白头翁汤、凉膈散配合SASP灌肠(肺肠同治组),持续60 d,各组治疗前后分别进行肠镜检查以作出临床疗效评价,并对患者血红蛋白(Hb),肝功能进行检测。结果:各组临床疗效评价:肺肠同治组>治肠组>对照组,差异有统计学意义(P<0.05);就Hb及肝功能而言:各组治疗前后比较,Hb皆有降低,ALT、AST皆有升高,差异有统计学意义(其中对照组、治肠组P<0.01,肺肠同治组P<0.05);各组治疗后比较,Hb为肺肠同治组>治肠组>对照组,ALT、AST为对照组>治肠组>肺肠同治组,差异有统计学意义(P<0.05)。结论:肺肠同治理论不仅对中医药与SASP协同灌肠治UC的增效研究具有指导意义,同样适用于其解毒效应研究。

Objective：To reveal the synergistic effect and detoxification of SASP enema to UC under the guidance of synchro- nous treatment of lung and intestine and to prove the scientificalness of method theory. Methods ： 60 cases of heat toxin syndrome UC patients were divided into control group （20 cases）, treatment of intestine group （20 cases） and synchronous treatment of lung and intestine group （20 cases） randomly. The control group used SASP for enema. The treatment of intestine group used SASP with Baitouweng Decoction and Tiaowei Chengqi Decoction for enema. The synchronous treatment of lung and intestine group used SASP with Baitouweng Decoction and Liangge Powder for enema, lasting for 60 days. The clinical evaluation was car- ried on and Hb and liver function were tested before and after treatment. Results ： The clinical effect in three groups ： synchronous treatment of lung and intestine group 〉 treatment of intestine group 〉 control group. As for Hb and liver function, Hb level was de- creased and ALT and AST levels were increased in three groups after treatment （control group, treatment of intestine group, P 〈 0. 01 ） ;synchronous treatment of lung and intestine group （P 〈 0. 05 ） and Hb showed that treatment of lung and intestine group 〉 treatment of intestine group 〉 control group while ALT and AST showed that control group 〉 treatment of intestine group 〉 treatment of lung and intestine group. Conclusion ： Enema therapy of synchronous treatment of lung and intestine has guiding significance both on UC clinical effect and detoxification to SASP.